The OKT4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV). CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation (together with the MHC class II). The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding. OKT4單克隆抗體特異性結(jié)合CD4受體為人類免疫缺陷病毒（HIV）。 CD4是一個59 kDa的單鏈跨膜糖蛋白，其表達(dá)的大多數(shù)的胸腺細(xì)胞，T輔助細(xì)胞的表面上，并在低的水平上的單核細(xì)胞和巨噬細(xì)胞。 CD4是一個共受體在抗原誘導(dǎo)的T細(xì)胞活化（第II類MHC在一起）。的OKT4和RPA-T4的單克隆抗體識別的CD4的不同表位和它們不表現(xiàn)出交叉阻斷結(jié)合。 Clone | OKT4 | Format: | FITC | Applications | FC | Reactivity | Human | Isotype: | Mouse IgG2b, kappa | | Research Interest: | Adaptive Immunity | | Cell Type: | Monocytes and Macrophages, T Cells, Treg cells, Th17 cells | Preperation: | The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product. | Formulation: | Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. | References: | Reinherz, E. L., Kung, P. C., Goldstein, G., & Schlossman, S. F. (1979). Separation of functional subsets of human T cells by a monoclonal antibody.Proceedings of the National Academy of Sciences, 76(8), 4061-4065. Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989. Bour, S. T. E. P. H. A. N. E., Boulerice, F. R. A. N. C. O. I. S., & Wainberg, M. A. (1991). Inhibition of gp160 and CD4 maturation in U937 cells after both defective and productive infections by human immunodeficiency virus type 1.Journal of virology, 65(12), 6387-6396. |
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